The Art of Process Chemistry. Nobuyoshi Yasuda

The Art of Process Chemistry



Download The Art of Process Chemistry



The Art of Process Chemistry Nobuyoshi Yasuda ebook pdf
Publisher: Wiley-VCH
Language: English
Page: 291
ISBN: 3527324704, 9783527324705

Review

"The book will be of great value to students looking to move into a career in process research; the enthusiasm and commitment of the authors comes over in the text, and the attention to detail and emphasis on mechanistic evaluation is a lesson to all. Academics will find much material that can be used in teaching . . . so in conclusion, this is an outstanding book which discusses the art of process research and developing process understanding." (Organic Process, Research & Development Journal, 17 December 2010)

From the Back Cover

The refinement of a chemical process to the point where it becomes both cost and time efficient can be seen as "art." In a competitive environment where pharmaceutical companies are under ever increasing pressure to bring new drugs more quickly to the market, ways need to be found to provide bulk supplies of drug candidates as quickly as possible and to design manufacturing routes, which are robust, economical and environmentally firendly. This monograph is divided into 9 chapters, each one concentrating on a single class of drug candidates of chemistry development and describing the routes explored and the optimizations made to each drug candidate, inluding the discovery of applicable new chemistry and the elucidation of reaction mechanism.

From the contents:Efairenz®, a Non-Nucleoside Reverse Transciptase Inhibitor (NNRTI), and a Previous Structurally Related Development CandidateCCR5 Receptor Antagonist5α-Reductase Inhibitors – The Finsteride StoryRizatriptan (Maxalt®): A 5-HT1D Receptor AgonistSERM: Selective Estrogen Receptor ModulatorHIV Integrase Inhibitor: RaltegravirCyclopentane-Based NK1 Receptor AntagonistGlucokinase ActivatorCB1R Inverse Agonist – Taranabant



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